Changing the Sentence Forever

"Are there any options left for AL Amyloidosis?"
Because of Immix, the answer is finally: "Yes."

We’ve found a breakthrough to change that hopeless sentence. Our mission is simple:
Create medicines that work without destroying the person.

The Current Paradigm is Failing

When AL Amyloidosis Comes Back, There's Nowhere to Turn

There are no FDA-approved drugs for relapsed/refractory AL amyloidosis. Doctors are forced to recycle old drug combinations, knowing they’ll fail again. Current treatments produce a devastating 0-10% complete response rate.
For patients with this rare, deadly disease—where toxic proteins attack vital organs, especially the heart—this isn’t just a statistic. It’s a death sentence.

AL Amyloidosis vs Healthy

Introducing NXC-201

We Re-Engineer the Immune System

to Fight for You Again

NXC-201 is a revolutionary one-time CAR-T therapy that harnesses the power of your own immune system to eliminate the diseased cells causing AL amyloidosis, targeting the root cause.


Through advanced engineering, we’ve created a treatment that’s both extraordinarily effective and remarkably safe, addressing the critical limitations that have made other therapies impossible for this vulnerable patient population.

Normalizes Disease Within Days

Diseased light chains return to normal levels within a median of just 7 days after treatment, giving your organs the chance to heal.

Single Infusion, Durable Response

Unlike ongoing treatment regimens, NXC-201 requires just one infusion. Your re-engineered immune cells continue working long-term.

Designed for Safety

Zero neurotoxicity. Minimal side effects. The shortest cytokine release syndrome duration of any BCMA CAR-T, critical for protecting vulnerable hearts.

THE SCIENCE BEHIND THE BREAKTHROUGH

Sterically Optimized
Makes the Difference

All BCMA CAR-Ts are not created equal

NXC-201 features three proprietary modifications that deliver “digital” signaling precision while dramatically reducing side effects, particularly critical for AL amyloidosis patients whose primary cause of mortality is heart failure.

Optimized CD3ζγ Signaling

Delivers precise “digital” intracellular signaling, reducing non‑specific activation and cytokine release.

Enhanced CD8 Hinge

Acts as a “digital filter” preventing inappropriate T-cell activation and further reducing CRS risk.

COBRA Binder Technology

Improves plasma cell binding and expression while maintaining flexibility for optimal function.

ASH 2025 Data

Extraordinary Results in Clinical Trials

Unprecedented outcomes in one of medicine’s most challenging diseases. Our U.S. NEXICART-2 registrational trial is delivering results that are transforming the treatment landscape for relapsed/refractory AL amyloidosis.

Current Standard of Care

0%

Complete Response Rate
(Investigator’s Choice)

With NXC‑201

0%

Complete Response Rate

(NEXICART‑2, ASH 2025)
BREAKTHROUGH

"An early and deep hematologic response has been found to lead to significantly prolonged survival."

Vaishali Sanchorawala, M.D.

Professor of Hematology and Oncology
Director, Amyloidosis Center at Boston University School of Medicine

0/20

Patients

Normalized disease markers

0 Days

Median Time

To response

0%

Neurotoxicity

Across all patients

4-8x

Shorter CRS

vs. other BMCA CAR-Ts

Beyond AL Amyloidosis: A Platform Built to Transform Multiple Diseases

Immix is laser focused on establishing NXC‑201 as the standard of care for relapsed/refractory AL amyloidosis. Our breakthrough also represents far more than a single‑disease solution.

NXC‑201 targets plasma cells, the antibody factories of the immune system. Success in AL amyloidosis validates our approach and opens the door to treating dozens of immune‑mediated diseases affecting millions of patients worldwide.

Neurology

Rheumatology

Hematology

Vascular & More

$10B+

Total Addressable Market

Across plasma cell-driven immune diseases, with AL amyloidosis alone representing $1.4-2.8 billion in annual sales potential

Beyond AL Amyloidosis: A Platform Built to Transform Multiple Diseases

Immix is laser focused on establishing NXC‑201 as the standard of care for relapsed/refractory AL amyloidosis. Our breakthrough also represents far more than a single‑disease solution.

NXC‑201 targets plasma cells, the antibody factories of the immune system. Success in AL amyloidosis validates our approach and opens the door to treating dozens of immune‑mediated diseases affecting millions of patients worldwide.

Neurology

Rheumatology

Hematology

Vascular & More

$10B+

Total Addressable Market

Across plasma cell-driven immune diseases, with AL amyloidosis alone representing $1.4-2.8 billion in annual sales potential

INVEST IN THE FUTURE

Al Amyloidosis and Other Serious Diseases... Cell Therapy Clinical Trailblazer

Immix Biopharma is a clinical-stage biopharmaceutical company trailblazing cell therapies in AL Amyloidosis and select other serious diseases. Our lead candidate is sterically-optimized BCMA-targeted chimeric antigen receptor T (CAR-T) cell therapy NXC-201. NXC-201 is being evaluated in the U.S. Phase 1b/2a trial NEXICART-2 as well as the ex-U.S. study NEXICART-1.

Want to Learn More?

Download our investor presentation to get all the latest information available.

Latest News

We Are on the Brink of

Turning Despair into Hope

Our progress is accelerating toward commercial launch

Founded Immix Biopharma to change the sentence for patients

2022
  • Systematic search launched and concluded to identify breakthrough cell therapies
  • Licensed-in global rights intellectual property from Hadassah Israel
2023-2024
  • FDA Orphan Drug & FDA Designations secured
  • NEXICART‑1 ex‑U.S. trial: 75% complete response rate
  • Mentioned in NEJM AL Amyloidosis review
Q1 2025
  • Published in Journal of Clinical Oncology
Q2 2025
  • American Society of Clinical Oncology (ASCO) Oral Presentation
Q4 2025
  • American Society of Hematology (ASH) Oral Presentation
  • Onboarded Chief Commercial Officer
2026
  • Received FDA Breakthrough Therapy Designation
Coming Next
  • BLA submission to FDA
  • Commercial Launch
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For Patients

If you’ve been diagnosed with relapsed or refractory AL amyloidosis, our clinical trial may offer hope. Learn about eligibility and enrollment.


For Physicians

We’re expanding our network of trial sites. Learn how to refer eligible patients or establish your center as a trial site.



Group

For Investors

Late‑stage biotech with breakthrough clinical data, clear regulatory path, and platform potential worth billions.



Meet the Team

Meet our team of innovators and thinkers at Immix Biopharma, whose dedication and expertise are paving the way for revolutionary treatments in AL Amyloidosis and other serious diseases.

We Are on the Brink of

Turning Despair Into Hope

Billions in market potential. Millions of lives changed. This is just the beginning.