Clinical Stage CAR-T for AL Amyloidosis and immune-mediated diseases
INVEST IN THE FUTURE
AL AMYLOIDOSIS AND immune-mediated disease CAR-T CLINICAL TRAILBLAZER
Immix Biopharma is a clinical-stage biopharmaceutical company trailblazing cell therapies in AL Amyloidosis and immune-mediated diseases. Our lead candidate is sterically-optimized BCMA-targeted chimeric antigen receptor T (CAR-T) cell therapy NXC-201. NXC-201 is being evaluated in the U.S. Phase 1b/2a trial NEXICART-2 as well as the ex-U.S. study NEXICART-1.
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RECENT EVENTS
RECENT NEWS
Immix Biopharma Advances CAR-T NXC-201 to Expansion Cohort Dose Level in U.S. AL Amyloidosis Trial NEXICART-2
Now dosing at dose expansion level of 450 million NXC-201 CAR+T cells. First cohort at 150 million CAR+T cells already...
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Immix Biopharma Announces Dr. Raymond Comenzo, Internationally Recognized AL Amyloidosis Expert, Director of the Myeloma and Amyloid Program at Tufts Medical Center, Joins Scientific Advisory Board
Dr. Comenzo was the senior author of the landmark Andromeda trial results published in the New England Journal of Medicine...
Read MoreImmix Biopharma Expands U.S. Clinical Sites for relapsed/refractory AL Amyloidosis Trial NEXICART-2
New Sites Expand Opportunities for Patient Access and Enrollment Clinical Trial Sites Added Include Cleveland Clinic, UC Davis, and Sutter...
Read MoreCalifornia Institute for Regenerative Medicine Awards Funding for CAR-T NXC-201 U.S. AL Amyloidosis Clinical Trial (NEXICART-2)
$8 million grant funds development of NXC-201 in relapsed/refractory AL Amyloidosis LOS ANGELES, CA, July 25, 2024 — Immix Biopharma,...
Read MoreINVESTOR INFORMATION NAVIGATION
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CORPORATE HIGHLIGHTS
Initiates Patient Dosing in NEXICART-2 trial
Lead site Memorial Sloan Kettering Cancer Center (MSKCC) for US AL Amyloidosis NXC-201 clinical trial.
FDA APPROVAL OF IND APPLICATION FOR NXC-201
Opens up ability to treat patients in the US. Favorable tolerability enables potential expansion into immune-mediated disease indications.
MULTIPLE SCIENTIFIC BOARD MEMBERS ADDED
Valuable expertise added from esteemed institutions, giving enhanced perspectives to our team
N-GENIUS CELL THERAPY PLATFORM
Possibility for additional cell therapies beyond current focus including possible expansion into immune-mediated disease indications
FOUNDATIONAL EXCELLENCE
Paving the Way for Revolutionary Treatments
Comprehensive Clinical Foundation
Building on one of the largest clinical datasets in the CAR-T industry, Immix Biopharma has established a strong foothold in advancing CAR-T therapies.
Pivotal Tolerability Milestone
Central to this achievement is the compelling evidence from a study involving 63 myeloma patients, pivotal in establishing the favorable tolerability profile of NXC-201, even when administered at high doses.
Stepping Stone to New Therapies
This foundational data serves as a critical stepping stone for exploring broader applications, providing a robust basis for venturing into new therapeutic areas.
Opportunity in AL Amyloidosis
Such a strong safety profile is especially significant as we turn our focus towards AL Amyloidosis—a condition with no approved therapies or other therapies in development.
Validating Future Directions
The initial positive outcomes from the first 13 AL patients further validate our approach and reinforce our commitment to expanding treatment horizons.
Expanding Treatment Horizons
Building on our success with AL Amyloidosis, we’re advancing our CAR-T technology to tackle a broad array of immune-mediated diseases, extending our reach and impact.
WHERE WE ARE
By leveraging the established tolerability of NXC-201, Immix Biopharma is poised to offer new hope to patients suffering from AL Amyloidosis. The initial positive outcomes from the first AL patients treated further validate our approach and reinforce our commitment to expanding treatment horizons.
Memorial Sloan Kettering Cancer Center in NYC recently named as the lead clinical site for the NXC-201 relapsed/refractory AL Amyloidosis multi-site clinical trial.
On track to dose relapsed/refractory AL Amyloidosis patients with CAR-T NXC-201 at New York City lead site and other leading U.S. sites mid-2024
Patients Being Dosed
From December 2022 through December 2023, went from ~10 patients dosed with NXC-201 to 72 patients dosed
FDA Orphan Drug Designation
Received FDA Orphan Drug Designation for NXC-201 for AL Amyloidosis
FDA Orphan Drug Designation
Received FDA Orphan Drug Designation for NXC-201 for multiple myeloma
Publications & Presentations
Published in Haematologica, presented at the American Society for Gene and Cell Therapy, the International Myeloma Society, invited to present at the 65th American Society for Hematology
Scientific Advisor Additions
Memorial Sloan Kettering, Stanford, and Columbia University members joined Scientific Advisory Board
NXC-201 Produced for U.S. AL Amyloidosis Dosing
Produced 3 U.S. manufacturing batches of CAR-T NXC-201 for onboarding of U.S. clinical trials
NXC-201 U.S. First Patient Dosed
Dosed first patient in U.S. AL Amyloidosis clinical trial
BLUE OCEAN OPPORTUNITY
In relapsed/refractory AL Amyloidosis there are no drugs approved today (Amyloidosis is a $3 billion dollar market according to Grand View Research).
A BETTER SOLUTION
AL Amyloidosis: NXC-201 currently Phase 1b/2a clinical trial CAR-T NXC-201 in relapsed/refractory AL Amyloidosis: 92% overall response rate in clinical trials ($3B market)
Received FDA Orphan Drug Designation for NXC-201 for AL Amyloidosis. On Track to Dose NXC-201 Patients in United States.
AL AMYLOIDOSIS MARKET
INDUSTRY LEADING PARTNERS
Immix Biopharma collaborates with top-tier industry leaders to accelerate our research and development efforts. Together, we are committed to advancing groundbreaking therapies that promise to transform patient outcomes in AL Amyloidosis and immune-mediated diseases.
GOING BEYOND AL
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